Bcr133 pdf

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Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Taylor Brian J. His research and teaching interests include decision making, assessment, care planning, risk and evidence-based practice.

E-mail: bj. Oxford Academic. Google Scholar. Cite Cite Brian J. Select Format Select format. Permissions Icon Permissions. Abstract Assessment is central to identifying needs, making decisions and providing services. Community care , assessment , integrated health and social care , Northern Ireland , person-centred care , multi-professional working , older people , test construction , tool development , social work.

All rights reserved. Issue Section:. You do not currently have access to this article. Download all slides. Sign in Don't already have an Oxford Academic account? Perturbation of this molecular system can provide cells resistant to tamoxifen through an increased agonist response. Recent in vitro studies indicate that MCF7 cells may become resistant to oestrogen deprivation by acquired hypersensitivity to oestrogen. There are clinical data to support this mechanism, and new clinical trials have been designed to determine whether this phenomenon can be utilised in sequential therapy.

To achieve optimal clinical exploitation of the progress in molecular endocrinology, there is a need for novel clinical trial design, which will utilise imaging and molecular pathological techniques for assessing the molecular response of tissues.

Neoadjuvant treatment of breast cancer offers unique advantages for such studies. Treatment-induced changes in proliferation are a useful intermediate endpoint for the evaluation of molecular relationships in breast carcinomas in vivo and for the assessment of drugs effecting these relationships.

You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Dowsett, M. Clinical translation of progress in molecular endocrinology. Breast Cancer Res 2, S. Download citation. Published : 12 March